Leentvaar-Kuijpers A, Coutinho R A, Brulein V, Safary A
Municipal Health Service, Amsterdam, The Netherlands.
Vaccine. 1992;10 Suppl 1:S138-41. doi: 10.1016/0264-410x(92)90569-6.
The serum antibody response to simultaneous administration of immune globulin (Ig) and an inactivated hepatitis A vaccine was investigated in healthy volunteers who had been tested and found free of hepatitis A virus. One hundred and forty nine subjects were randomly allocated into three groups. Group 1 received three doses of hepatitis A vaccine at 0, 1 and 6 months, group 2 received 5 ml of Ig and group 3 received a combination of Ig and vaccine. In group 3 the seropositivity rate measured by enzyme-linked immunosorbent assay was 100% at day 5, month 1 and 2, 96% at month 6 and again 100% at month 7. In the group that received vaccine alone the seroconversion rates were 0, 96, 100, 98 and 100 respectively. The geometric mean titres in subjects who received passive/active immunization were about twofold lower than in subjects who received vaccine alone, indicating interference of Ig with the immune response. Despite this, the data show that simultaneous administration of hepatitis A vaccine and Ig confers both immediate protection via Ig administration and long-term vaccine-induced protection. As the antibody levels reached are about twofold lower compared to that after administration of hepatitis A vaccine alone, a booster dose may be required sooner, than if the vaccine were administered alone.
在已检测且未感染甲型肝炎病毒的健康志愿者中，研究了同时接种免疫球蛋白（Ig）和甲型肝炎灭活疫苗后的血清抗体反应。149名受试者被随机分为三组。第1组在0、1和6个月时接种三剂甲型肝炎疫苗，第2组接种5毫升Ig，第3组接种Ig和疫苗的组合。在第3组中，通过酶联免疫吸附测定法测得的血清阳性率在第5天、第1个月和第2个月时为100%，第6个月时为96%，第7个月时再次为100%。在仅接种疫苗的组中，血清转化率分别为0、96%、100%、98%和100%。接受被动/主动免疫的受试者的几何平均滴度比仅接受疫苗的受试者低约两倍，表明Ig对免疫反应有干扰。尽管如此，数据表明同时接种甲型肝炎疫苗和Ig既能通过接种Ig提供即时保护，又能通过疫苗诱导长期保护。由于与单独接种甲型肝炎疫苗后相比，所达到的抗体水平低约两倍，可能比单独接种疫苗时更早需要加强剂量。
