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Inhibitors of lipopolysaccharide biosynthesis impair the virulence potential of Escherichia coli.

作者信息

Hammond S M

机构信息

Department of Microbiology, Glaxo SpA, Verona, Italy.

出版信息

FEMS Microbiol Lett. 1992 Dec 15;100(1-3):293-7. doi: 10.1111/j.1574-6968.1992.tb14055.x.

DOI:10.1111/j.1574-6968.1992.tb14055.x
PMID:1335947
Abstract

Inhibition of 3-deoxy-manno-octulosonate cytidylytransferase (CMP-KDO transferase; EC 2.7.7.38) by 8-amino-2,6-anhydro-3,8-dideoxy-D-glycero-D-talo-octonic acid (NH2dKDO) halts the growth of Gram-negative bacteria by depriving the cells of the 3-deoxy-D-manno-2-octulosonate required for the biosynthesis of the core region of the lipopolysaccharide components of the outer membrane. Low levels of this inhibitor increase the vulnerability of Escherichia coli to hydrophobic antibiotics, detergents, the complement-mediated antibacterial activity of serum, phagocytosis, and enhance the rate at which bacteria are cleared from the mouse bloodstream.

摘要

相似文献

1
Inhibitors of lipopolysaccharide biosynthesis impair the virulence potential of Escherichia coli.
FEMS Microbiol Lett. 1992 Dec 15;100(1-3):293-7. doi: 10.1111/j.1574-6968.1992.tb14055.x.
2
Antibacterial agents specifically inhibiting lipopolysaccharide synthesis.
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3
A novel prodrug of an impermeant inhibitor of 3-deoxy-D-manno-2-octulosonate cytidylyltransferase has antibacterial activity.一种新型的3-脱氧-D-甘露-2-辛酮酸胞苷转移酶非渗透性抑制剂前药具有抗菌活性。
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Design and synthesis of peptide derivatives of a 3-deoxy-D-manno-2-octulosonic acid (KDO) analogue as novel antibacterial agents acting upon lipopolysaccharide biosynthesis.作为作用于脂多糖生物合成的新型抗菌剂的3-脱氧-D-甘露-2-辛酮糖酸（KDO）类似物的肽衍生物的设计与合成
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Accumulation of incomplete metabolic side products of lipid A in Salmonella typhimurium during inhibition of 3-deoxy-D-manno-octulosonate incorporation by a new class of antibacterial agents.
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7
Analysis of lipopolysaccharide biosynthesis in Salmonella typhimurium and Escherichia coli by using agents which specifically block incorporation of 3-deoxy-D-manno-octulosonate.利用特异性阻断3-脱氧-D-甘露辛酮糖酸掺入的试剂对鼠伤寒沙门氏菌和大肠杆菌中脂多糖生物合成的分析
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Synthesis of analogues of 3-deoxy-D-manno-octulosonic acid (KDO) as potential inhibitors of CMP-KDO synthetase.3-脱氧-D-甘露糖辛酮酸（KDO）类似物的合成作为CMP-KDO合成酶的潜在抑制剂
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J Biol Chem. 2017 Dec 1;292(48):19840-19848. doi: 10.1074/jbc.M117.814962. Epub 2017 Oct 9.

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