A 2-deoxy analogue of KDO as the first inhibitor of the enzyme CMP-KDO synthetase.
作者信息
Claesson A, Luthman K, Gustafsson K, Bondesson G
出版信息
Biochem Biophys Res Commun. 1987 Mar 30;143(3):1063-8. doi: 10.1016/0006-291x(87)90360-3.
PMID:3032181
Abstract
The two KDO analogues 2,6-anhydro-3-deoxy-D-glycero-D-galacto-octonate and 2,6-anhydro-3-deoxy-D-glycero-D-talo-octonate were synthesized and tested as inhibitors of the enzyme CTP:CMP-deoxyoctulosonate cytidylyltransferase (CMP-KDO synthetase) from Gram-negative bacteria. Only compound 4, the 2-deoxy analogue of beta-KDO-pyranose, was found to be an inhibitor with a Ki of 3.9 microM.
摘要
Zotero 插件