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细胞遗传学暗室魔法:现在你看到它们了,现在又看不到了。

Cytogenetic darkroom magic: now you see them, now you don't.

作者信息

Overton K M, Magenis R E, Brady T, Chamberlin J, Parks M

出版信息

Am J Hum Genet. 1976 Jul;28(4):417-9.

Abstract

Customary procedures used to determine chromosomal inheritance do not disclose many of the chromosomal polymorphisms known to be present, resulting in uninformative families. The sequential printing of individual chromosomes presented here is a technique that has increased the number of informative families in our studies. This technique has revealed previously unseen heritable chromosome differences and allowed the designation of parental origin.

摘要

用于确定染色体遗传的传统程序并未揭示许多已知存在的染色体多态性,从而导致家系信息不足。本文介绍的单个染色体逐次打印技术增加了我们研究中有信息价值家系的数量。该技术揭示了以前未被发现的可遗传染色体差异,并确定了亲本来源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8b9/1685056/9afbfe7caa25/ajhg00214-0104-a.jpg

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