Lambert M, Pirson Y, De Nayer P, van Ypersele de Strihou C
Department of General Internal Medicine, Cliniques Universitaires St Luc, Université Catholique de Louvain, Bruxelles, Belgium.
Nephrol Dial Transplant. 1992;7(11):1082-4.
The presence of circulating antithyroid antibodies in a small number of patients with Alport's syndrome has led some to suggest that the two abnormalities are associated. If confirmed, such an association could have important diagnostic as well as pathophysiological implications. Using sensitive methods, we assessed the prevalence of antithyroid antibodies in 40 patients with Alport's syndrome from 28 families. Antithyroglobulin antibodies were absent in all patients. Antimicrosomal and antithyroperoxidase antibodies were absent in all but one patient. Three patients with Alport's syndrome from the latter family were negative for antithyroid antibodies. In this large number of patients we found no association between Alport's syndrome and antithyroid antibodies. Screening for the presence of such antibodies in patients with Alport's syndrome is thus not warranted. The previously reported coexistence of the two disorders might be fortuitous.
少数奥尔波特综合征患者体内存在循环抗甲状腺抗体，这使得一些人认为这两种异常情况有关联。如果得到证实，这种关联可能具有重要的诊断及病理生理学意义。我们采用灵敏的方法，评估了来自28个家庭的40例奥尔波特综合征患者抗甲状腺抗体的患病率。所有患者均无抗甲状腺球蛋白抗体。除1例患者外，所有患者均无抗微粒体抗体和抗甲状腺过氧化物酶抗体。后一个家庭的3例奥尔波特综合征患者抗甲状腺抗体检测呈阴性。在大量此类患者中，我们未发现奥尔波特综合征与抗甲状腺抗体之间存在关联。因此，对奥尔波特综合征患者筛查此类抗体并无必要。此前报道的这两种病症共存情况可能是偶然的。
