Savige J A, Branley P, Neeson P, Holdsworth S, Thurlow P
University Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Australia.
Pathology. 1998 Feb;30(1):30-3. doi: 10.1080/00313029800169635.
The basement membranes of the glomerulus, thyroid and adrenal all contain the Goodpasture antigen, the target of autoantibodies in antiglomerular basement membrane (GBM) disease. Antithyroid antibodies can be associated with antiGBM disease, and there have been occasional reports of antithyroid antibodies in Alport syndrome, an inherited kidney disease where the GBM lacks the Goodpasture antigen. The aim of this study was to determine how often antithyroid and antiadrenal autoantibodies occurred in antiGBM disease, Alport syndrome and a related condition, thin basement membrane disease (TBMD). Sera from patients with antiGBM disease (n = 19), Alport syndrome (n = 5) or TBMD (n = 13) were tested for antithyroglobulin, antithyroid microsomal and antiadrenal antibodies. Five of the patients with antiGBM disease (5/19, 26%, P NS) had antimicrosomal, and one had antithyroglobulin, antibodies (1/19, 5%, P NS). No patient with Alport syndrome had antithyroid antibodies. One with TBMD (1/13, 8%, P NS) had antithyroglobulin and antimicrosomal antibodies at titres of 1/400 and 1/25,600, respectively. Both patients with antithyroglobulin antibodies had previously been diagnosed with hypothyroidism. No one with antiGBM disease, Alport syndrome or TBMD had antiadrenal antibodies. Antithyroid microsomal antibodies do not occur significantly more often in patients with antiGBM disease than in normals, and antithyroid and antiadrenal antibodies are not associated with Alport syndrome or TBMD.
肾小球、甲状腺和肾上腺的基底膜均含有Goodpasture抗原，它是抗肾小球基底膜（GBM）病中自身抗体的靶抗原。抗甲状腺抗体可与抗GBM病相关，并且在Alport综合征（一种遗传性肾病，其GBM缺乏Goodpasture抗原）中偶尔也有抗甲状腺抗体的报道。本研究的目的是确定抗甲状腺和抗肾上腺自身抗体在抗GBM病、Alport综合征及一种相关病症——薄基底膜病（TBMD）中出现的频率。检测了抗GBM病患者（n = 19）、Alport综合征患者（n = 5）或TBMD患者（n = 13）血清中的抗甲状腺球蛋白、抗甲状腺微粒体和抗肾上腺抗体。抗GBM病患者中有5例（5/19，26%，P无统计学意义）有抗微粒体抗体，1例有抗甲状腺球蛋白抗体（1/19，5%，P无统计学意义）。Alport综合征患者均无抗甲状腺抗体。1例TBMD患者（1/13，8%，P无统计学意义）有抗甲状腺球蛋白和抗微粒体抗体，滴度分别为1/400和1/25,600。两名有抗甲状腺球蛋白抗体的患者此前均被诊断为甲状腺功能减退。抗GBM病、Alport综合征或TBMD患者均无抗肾上腺抗体。抗GBM病患者中抗甲状腺微粒体抗体的出现频率并不显著高于正常人群，抗甲状腺和抗肾上腺抗体与Alport综合征或TBMD无关。
