Stafekhina V S
Zh Vyssh Nerv Deiat Im I P Pavlova. 1992 Sep-Oct;42(5):955-64.
Were compared electrophysiological characteristics of suspension (SUS) and solid (SOL) tissue grafts of embryonic neocortex transplanted into the barrel field of adult rats. The level of survival of SUS and SOL grafts did not differ significantly (89% and 95% correspondingly). All SUS grafts were integrated with the host brain judging by histological and electrophysiological criteria. Reactivity of neurons to electrical stimulation of the recipient's brain and to sensory (tactile) stimulation, as well as the latencies of on-responses were similar in both types of the grafts. However, proportion of neurons with on-responses was nearly twice lower in SUS grafts, while the number of neurons responding to tactile stimulation by primary suppression of activity was significantly higher than in SOL ones. It is suggested that the derangement of primary architectonics unavoidable during preparation of suspensions is responsible for the described differences between SUS and SOL grafts.
比较了移植到成年大鼠桶状皮质区的胚胎新皮质悬浮（SUS）组织移植物和实体（SOL）组织移植物的电生理特性。SUS和SOL移植物的存活水平无显著差异（分别为89%和95%）。根据组织学和电生理标准判断，所有SUS移植物均与宿主脑整合。两种移植物中，神经元对受体脑电刺激和感觉（触觉）刺激的反应性以及开启反应的潜伏期相似。然而，SUS移植物中具有开启反应的神经元比例几乎低了近两倍，而通过活动的初级抑制对触觉刺激作出反应的神经元数量显著高于SOL移植物。提示在制备悬浮液过程中不可避免的初级结构紊乱是导致SUS和SOL移植物之间上述差异的原因。
