Kouno S, Adachi M, Asano K, Okamoto K, Takahashi T
First Department of Internal Medicine, Showa University School of Medicine.
Arerugi. 1992 Oct;41(10):1488-91.
The effects of IPD-1151T (suplatast tosilate), a novel anti-allergic drug, on murine mast cell induction were examined by the in vitro cell culture technique. Spleen cells from BALB/c mice suspended in RPMI-1640 medium containing interleukin 3 were cultured in the presence or absence of IPD-1151T. Half the volume of the medium was changed every 4 days. Mast cell numbers increased as the culture time went on and reached a peak on the 16th day, when spleen cells were cultured without IPD-1151T. However, induction of mast cells from spleen cell cultures was inhibited by IPD-1151T in a dose dependent fashion. These results strongly suggest that IPD-1151T is a very useful agent for therapy in allergic diseases.
采用体外细胞培养技术，研究了新型抗过敏药物IPD - 1151T（托西酸舒拉他定）对小鼠肥大细胞诱导的影响。将悬浮于含白细胞介素3的RPMI - 1640培养基中的BALB/c小鼠脾细胞，在有或无IPD - 1151T的情况下进行培养。每4天更换一半体积的培养基。当脾细胞在无IPD - 1151T的情况下培养时，肥大细胞数量随培养时间增加而增多，并在第16天达到峰值。然而，IPD - 1151T以剂量依赖性方式抑制脾细胞培养物中肥大细胞的诱导。这些结果强烈表明，IPD - 1151T是治疗过敏性疾病的非常有用的药物。
