IPD-1151T（苏普拉他定 Tosilate）对正常小鼠脾细胞诱导肥大细胞的抑制作用。
Suppressive effects of IPD-1151T (suplatast-tosilate) on induction of mast cells from normal mouse splenocytes.
作者信息
Konno S, Adachi M, Asano K, Gonogami Y, Ikeda K, Okamoto K, Takahashi T
机构信息
First Department of Internal Medicine, School of Medicine, Showa University, Tokyo, Japan.
出版信息
Eur J Pharmacol. 1994 Jun 23;259(1):15-20. doi: 10.1016/0014-2999(94)90151-1.
The influence of IPD-1151T (suplatast-tosilate) on murine mast cell induction was examined by in vitro cell culture. Splenocytes from BALB/c mice suspended in RPMI-1640 medium supplemented with interleukin-3 were cultured in the presence or absence of IPD-1151T. Half of the total volume of the medium was changed every 4-5 days. The number of mast cells increased with culture time and reached a peak on the 16th day when the cells were cultured without IPD-1151T. However, the growth of mast cells from the splenocyte culture was dose dependently inhibited by IPD-1151T. Furthermore, IPD-1151T inhibited the proliferation of mast cell progenitor cells, IC-2, but not that of splenocytes or mature mast cells.
通过体外细胞培养研究了IPD - 1151T（托西酸舒拉酯）对小鼠肥大细胞诱导的影响。将悬浮于补充有白细胞介素 - 3的RPMI - 1640培养基中的BALB/c小鼠脾细胞在有或无IPD - 1151T的情况下进行培养。每4 - 5天更换一半总体积的培养基。在无IPD - 1151T培养细胞时，肥大细胞数量随培养时间增加，并在第16天达到峰值。然而，IPD - 1151T剂量依赖性地抑制了脾细胞培养物中肥大细胞的生长。此外，IPD - 1151T抑制肥大细胞祖细胞IC - 2的增殖，但不抑制脾细胞或成熟肥大细胞的增殖。
Zotero 插件