Pallen C J, Tan Y H, Guy G R
Cell Regulation Laboratory, National University of Singapore.
Curr Opin Cell Biol. 1992 Dec;4(6):1000-7. doi: 10.1016/0955-0674(92)90132-v.
Protein phosphorylation is the most common post-translational modification and plays a role in all known pathways of signal transduction. Net phosphorylation is a result of the balance of activities of protein kinases and phosphatases. There is increasing evidence that the regulated removal of phosphate groups from proteins, catalyzed by protein phosphatases, is required for the downstream activation of other signalling proteins.
蛋白质磷酸化是最常见的翻译后修饰，在所有已知的信号转导途径中都发挥着作用。净磷酸化是蛋白激酶和磷酸酶活性平衡的结果。越来越多的证据表明，由蛋白磷酸酶催化的从蛋白质上有调控地去除磷酸基团，对于其他信号蛋白的下游激活是必需的。
