Hack N, Schultz A, Clayman P, Goldberg H, Skorecki K L
Department of Medicine, Toronto Hospital, Canada.
Pediatr Nephrol. 1995 Aug;9(4):514-25. doi: 10.1007/BF00866743.
Transmembrane signal transduction is the process whereby a ligand binds to the external surface of the cell membrane and elicits a physiological response specific for that ligand and cell type. It is now appreciated that numerous disease states represent disturbances in normal transmembrane signaling mechanisms. In the current paper, we focus our attention on the mesangial cell of the glomerular microcirculation as a prototypical model system for understanding normal and abnormal transmembrane signaling processes. Among the major receptor and effector mechanisms for transmembrane signal transduction in the mesangial cell, this paper emphasizes the phospholipase effector response to growth factors and vasoactive hormones. The post-translational and transcriptional pathways for regulation of phospholipase C and phospholipase A2 are described, including consideration of perturbations in these systems that characterize two disease models, namely: acute cyclosporine nephrotoxicity and early diabetic glomerulopathy.
跨膜信号转导是指配体与细胞膜外表面结合并引发针对该配体和细胞类型的特定生理反应的过程。现在人们认识到，许多疾病状态代表了正常跨膜信号传导机制的紊乱。在本文中，我们将注意力集中在肾小球微循环的系膜细胞上，将其作为理解正常和异常跨膜信号传导过程的典型模型系统。在系膜细胞跨膜信号转导的主要受体和效应器机制中，本文重点强调磷脂酶对生长因子和血管活性激素的效应反应。描述了磷脂酶C和磷脂酶A2调节的翻译后和转录途径，包括对两种疾病模型（即急性环孢素肾毒性和早期糖尿病肾小球病）中这些系统扰动的考虑。
