备解素系统与免疫。VI. 备解素系统对新城疫病毒的灭活作用。
The properdin system and immunity. VI. The inactivation of Newcastle disease virus by the properdin system.
作者信息
GINSBERG H S, PILLEMER L, WEDGWOOD R J
出版信息
J Exp Med. 1956 Nov 1;104(5):707-25. doi: 10.1084/jem.104.5.707.
Abstract
Detailed experiments are presented which indicate that the properdin system is an inhibitor of Newcastle disease virus. Viral inhibition required all known components of the properdin system: properdin, all four components of complement and magnesium; the removal of any one constituent resulted in a loss of inhibition; the replacement of the constituent restored antiviral effect. The inhibition of virus was temperature-dependent. The process of inhibition by serum resulted in a decrease in the amount of properdin available in the serum without any measurable effect on the components of complement. The prolonged incubation of inactive serum-virus mixtures with cation-exchange resin resulted in the restoration of some, but not all, of the hemagglutinating activity of the virus. The requirements of the properdin system and the implication of these findings were discussed.
摘要
文中展示了详细的实验，这些实验表明备解素系统是新城疫病毒的一种抑制剂。病毒抑制需要备解素系统的所有已知成分：备解素、补体的所有四种成分以及镁；去除任何一种成分都会导致抑制作用丧失；该成分的替代则恢复抗病毒效果。病毒的抑制作用依赖于温度。血清抑制病毒的过程导致血清中可用备解素的量减少，而对补体成分没有任何可测量的影响。将无活性的血清 - 病毒混合物与阳离子交换树脂长时间孵育，导致病毒的一些（但不是全部）血凝活性恢复。文中讨论了备解素系统的要求以及这些发现的意义。
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本文引用的文献
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J Exp Med. 1947 Jan 1;85(1):1-7. doi: 10.1084/jem.85.1.1.
2
A labile component of normal serum which combines with various viruses; neutralization of infectivity and inhibition of hemagglutination by the component.正常血清中的一种不稳定成分，可与多种病毒结合；该成分可中和感染性并抑制血凝反应。
J Exp Med. 1949 Nov;90(5):475-95. doi: 10.1084/jem.90.5.475.
3
Factors involved in influenza haemagglutination reaction.流感血凝反应所涉及的因素。
Br J Exp Pathol. 1949 Feb;30(1):48-61.
4
The influence of certain serum factors on the neutralization of western equine encephalomyelitis virus.某些血清因子对西部马脑脊髓炎病毒中和作用的影响。
J Immunol. 1949 Jul;62(3):319-31.
5
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