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采用荧光技术对淀粉样蛋白进行免疫组织化学分析。

Immunohistochemical analysis of amyloid by the fluorescence technique.

作者信息

DIXON F J, VAZQUEZ J J

出版信息

J Exp Med. 1956 Nov 1;104(5):727-36. doi: 10.1084/jem.104.5.727.

DOI:10.1084/jem.104.5.727
PMID:13367340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2136616/
Abstract

The immunohistochemical composition of amyloid deposits in secondary human amyloidosis and experimental amyloidosis in rabbits was studied by means of the "fluorescent antibody" technique of Coons et al. Quantitative studies of the relative amounts of gamma globulin present in the amyloid deposits by the use of radioiodinated fluorescent antibody are reported. It is concluded that amyloid deposits in several organs from cases of secondary human amyloidosis and experimental amyloidosis in rabbits contain considerable concentrations of gamma globulin. The presence of gamma globulin in amyloid might be interpreted as either a metabolic deposition of circulating globulin present in high concentrations in the plasma or as a result of an immunologic reaction involving antigen and antibody.

摘要

采用孔斯等人的“荧光抗体”技术，对继发性人类淀粉样变性和兔实验性淀粉样变性中淀粉样沉积物的免疫组织化学组成进行了研究。报告了使用放射性碘化荧光抗体对淀粉样沉积物中γ球蛋白相对含量的定量研究。得出的结论是，继发性人类淀粉样变性病例和兔实验性淀粉样变性的几个器官中的淀粉样沉积物含有相当浓度的γ球蛋白。淀粉样物质中γ球蛋白的存在可解释为血浆中高浓度循环球蛋白的代谢沉积，或抗原与抗体免疫反应的结果。

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Immunohistochemical analysis of amyloid by the fluorescence technique.采用荧光技术对淀粉样蛋白进行免疫组织化学分析。
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本文引用的文献

1
Allergic hyperglobulinosis and hyalinosis (paramyloidosis) in the reticulo-endothelial system in Boeck's sarcoid and other conditions; a morphologic immunity reaction.结节病及其他病症中网状内皮系统的过敏性高球蛋白血症与透明变性（淀粉样变性）；一种形态学免疫反应。
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Antigen elimination from the blood as an early manifestation of the immune response.作为免疫反应早期表现的血液中抗原清除。
J Immunol. 1951 Oct;67(4):243-55.
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Studies of the composition of secondary amyloid.继发性淀粉样变的成分研究。
J Clin Invest. 1955 Sep;34(9):1476-82. doi: 10.1172/JCI103198.
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Primary systemic amyloidosis.原发性系统性淀粉样变性
Am J Med Sci. 1954 Sep;228(3):317-33.
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On the amyloid-Congo red complex in histological sections and the genesis of the amyloid substance.关于组织切片中的淀粉样蛋白-刚果红复合物及淀粉样物质的成因
Acta Anat (Basel). 1954;20(3):285-90. doi: 10.1159/000140904.
6
Fluorescein-conjugated bovine albumin; physical and biological properties.荧光素偶联牛血清白蛋白：物理及生物学特性
J Gen Physiol. 1953 Mar;36(4):489-506. doi: 10.1085/jgp.36.4.489.

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