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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Bansinath M, Warner W, Tang C K, Turndorf H, Puig M M

Department of Anesthesiology, New York University Medical Center, NY.

Gen Pharmacol. 1992 Nov;23(6):1183-7. doi: 10.1016/0306-3623(92)90309-8.

Electrically induced contraction of guinea pig ileum myenteric plexus-longitudinal muscle was inhibited by ketamine and halothane with IC50s of 2.1 x 10(-4) M and 1.8 v/v% respectively. 2. The inhibitory action of ketamine was partially antagonized by naloxone and the selective kappa antagonist nor-binaltorphimine. 3. The actions of ketamine and halothane were synergistic at high levels of response (above 30% inhibition). 4. The actions of ketamine and halothane became antagonistic after treatment with pertussis toxin. 5. The interaction of ketamine and halothane was similar to the interaction of morphine and halothane.

Bansinath M, Warner W, Tang C K, Turndorf H, Puig M M

Department of Anesthesiology, New York University Medical Center, NY.

Gen Pharmacol. 1992 Nov;23(6):1183-7. doi: 10.1016/0306-3623(92)90309-8.

Electrically induced contraction of guinea pig ileum myenteric plexus-longitudinal muscle was inhibited by ketamine and halothane with IC50s of 2.1 x 10(-4) M and 1.8 v/v% respectively. 2. The inhibitory action of ketamine was partially antagonized by naloxone and the selective kappa antagonist nor-binaltorphimine. 3. The actions of ketamine and halothane were synergistic at high levels of response (above 30% inhibition). 4. The actions of ketamine and halothane became antagonistic after treatment with pertussis toxin. 5. The interaction of ketamine and halothane was similar to the interaction of morphine and halothane.