空肠弯曲菌与大肠杆菌外膜孔蛋白之间的免疫交叉反应性。
Immunological cross-reactivity between outer membrane pore proteins of Campylobacter jejuni and Escherichia coli.
作者信息
Kervella M, Fauchère J L, Fourel D, Pagès J M
机构信息
Laboratoire de Bactériologie, Faculté de Médecine, Necker-Enfants Malades, Paris, France.
出版信息
FEMS Microbiol Lett. 1992 Dec 1;78(2-3):281-5. doi: 10.1016/0378-1097(92)90041-l.
Immunocrossreactivity between the major outer membrane protein (MOMP) of Campylobacter jejuni 85H and the OmpC porin of Escherichia coli K-12 was observed. These results indicate that a common antigenic domain is conserved in both MOMP and OmpC. This antigenic region is detected only after a 96 degrees C treatment suggesting that it is buried in the native conformation of the respective porins. In addition, differences were observed between the major outer membrane proteins from various C. jejuni strains. About 60% of the C. jejuni pathogenic strains tested contained a protein exhibiting a similar electrophoretic profile to the 85H porin.
观察到空肠弯曲菌85H的主要外膜蛋白（MOMP）与大肠杆菌K-12的OmpC孔蛋白之间存在免疫交叉反应性。这些结果表明，一个共同的抗原结构域在MOMP和OmpC中都是保守的。这个抗原区域只有在96℃处理后才能检测到，这表明它在各自孔蛋白的天然构象中是被掩埋的。此外，在不同空肠弯曲菌菌株的主要外膜蛋白之间也观察到了差异。所测试的约60%的空肠弯曲菌致病菌株含有一种蛋白，其电泳图谱与85H孔蛋白相似。
Zotero 插件