University of Florida and the Malcom Randall VA Medical Center, Gainesville, FL, USA.
Virulence. 2013 Apr 1;4(3):230-40. doi: 10.4161/viru.23753. Epub 2013 Feb 13.
Campylobacter jejuni is a major cause of food-borne gastroenteritis worldwide. While mortality is low, morbidity imparted by post-infectious sequelae such as Guillain-Barré syndrome, Reiter syndrome/reactive arthritis and irritable bowel syndrome is significant. In addition, the economic cost is high due to lost productivity. Food animals, particularly poultry, are the main reservoirs of C. jejuni. The over-use of antibiotics in the human population and in animal husbandry has led to an increase in antibiotic-resistant infections, particularly with fluoroquinolones. This is problematic because C. jejuni gastroenteritis is clinically indistinguishable from that caused by other bacterial pathogens, and such illnesses are usually treated empirically with fluoroquinolones. Since C. jejuni is naturally transformable, acquisition of additional genes imparting antibiotic resistance is likely. Therefore, an understanding of the antibiotic resistance mechanisms in C. jejuni is needed to provide proper therapy both to the veterinary and human populations.
空肠弯曲菌是全世界食源性肠胃炎的主要病因。虽然死亡率较低，但感染后的后遗症，如格林-巴利综合征、赖特综合征/反应性关节炎和肠易激综合征，会导致较高的发病率。此外，由于生产力的损失，其经济成本也很高。食用动物，特别是家禽，是空肠弯曲菌的主要宿主。人类和畜牧业中超量使用抗生素导致了抗生素耐药性感染的增加，特别是氟喹诺酮类药物。这是一个问题，因为空肠弯曲菌肠胃炎与其他细菌性病原体引起的肠胃炎在临床上无法区分，此类疾病通常用氟喹诺酮类药物进行经验性治疗。由于空肠弯曲菌具有天然的可转化性，因此获得赋予抗生素耐药性的其他基因的可能性很大。因此，了解空肠弯曲菌的抗生素耐药机制对于向兽医和人类群体提供适当的治疗非常重要。
