Martin F G
Department of Biology, Immaculata College, PA 19345.
J Exp Biol. 1992 Nov;172:387-402. doi: 10.1242/jeb.172.1.387.
The concept of electrical circuit analysis is extended to include components found in membrane ionic transport systems. As in classical electrical equivalent circuits, resistors and capacitors are used to represent ion channels and the membrane capacitances, respectively; batteries represent energy sources driven by chemical reactions. In the extensions proposed, energy stored in various ionic concentrations is treated as charges on compartmental capacitors; symporters and antiporters are treated as energy-coupling devices analogous to transformers in alternating current electrical circuits. Pumps are shown to be special cases of porters in which the input circuit derives its energy from a chemical reaction. Using these components, circuit diagrams are drawn for several examples of membrane ion transport systems. By applying appropriate circuit analysis techniques, these diagrams facilitate the quantitative description of the energy distributions throughout the system.
电路分析的概念得以扩展，以纳入膜离子转运系统中的组件。与经典的等效电路一样，电阻器和电容器分别用于表示离子通道和膜电容；电池代表由化学反应驱动的能量源。在所提出的扩展内容中，存储在各种离子浓度中的能量被视为隔室电容器上的电荷；同向转运体和反向转运体被视为类似于交流电路中变压器的能量耦合装置。泵被证明是转运体的特殊情况，其中输入电路从化学反应中获取能量。利用这些组件，绘制了几个膜离子转运系统示例的电路图。通过应用适当的电路分析技术，这些电路图有助于对整个系统中的能量分布进行定量描述。
