Okamoto H, Kawakami K
Department of Internal Medicine, Juntendo University School of Medicine.
Nihon Rinsho. 1992 Dec;50(12):2996-3003.
Na, K-ATPase is the enzyme responsible for the maintenance of the electrochemical gradients of Na+ and K+ across the plasma membrane. The enzyme consists of a heterodimer of an alpha and a beta subunits. Na, K-ATPase belongs to a multigene family. Three alpha subunit (alpha 1 alpha 2 alpha 3) and three beta subunit (beta 1 beta 2 beta 3) isoforms have been described so far. The gene expression of each subunit is differentially regulated in various tissues and developmental stages. To clarify the molecular mechanisms of the regulation of Na, K-ATPase gene expression and of the coordinated regulation between the alpha and beta subunit genes, extensive analyses of the genes encoding alpha and beta subunit isoforms have been performed. The rapid progress of the study in this field is reviewed.
钠钾ATP酶是负责维持钠离子和钾离子跨质膜电化学梯度的酶。该酶由一个α亚基和一个β亚基组成的异二聚体。钠钾ATP酶属于一个多基因家族。迄今为止，已描述了三种α亚基（α1、α2、α3）和三种β亚基（β1、β2、β3）同工型。每个亚基的基因表达在不同组织和发育阶段受到差异调节。为了阐明钠钾ATP酶基因表达调控以及α和β亚基基因之间协同调控的分子机制，已经对编码α和β亚基同工型的基因进行了广泛分析。本文综述了该领域研究的快速进展。
