Omori K, Matsuda H
Department of Physiology, Kansai Medical University, Japan.
Nihon Rinsho. 1996 Mar;54(3):586-94.
Na, K-ATPase is an integral plasma membrane protein and plays essential roles such as maintaining sodium and potassium ion gradients across the plasma membrane. The enzyme consists of the alpha and the beta subunits with the stoichiometry of one to one. Three alpha subunit and two beta subunit isoforms have been detected in animal cells with the tissue-specific expression of both subunits. Recent advances in molecular biological studies on the Na, K-ATPase enable us to understand the structure-function relationships and mechanisms of intracellular transport of the enzyme. In this article we review the findings deduced from these studies, especially on the assembly and transport to the plasma membrane of the alpha and beta subunits.
钠钾ATP酶是一种整合型质膜蛋白，在维持跨质膜的钠钾离子梯度等方面发挥着重要作用。该酶由α和β亚基组成，化学计量比为1:1。在动物细胞中已检测到三种α亚基和两种β亚基异构体，且两个亚基均有组织特异性表达。钠钾ATP酶分子生物学研究的最新进展使我们能够了解该酶的结构-功能关系及细胞内运输机制。在本文中，我们综述了这些研究得出的结果，特别是关于α和β亚基的组装及向质膜的运输。
