Labeeuw M, Prost N F, Daoud S, Lapra C, Zech P, Pozet N
Department of Nephrology, E. Herriot Hospital, Lyon, France.
Nephrol Dial Transplant. 1992;7(12):1190-3. doi: 10.1093/ndt/7.12.1190.
In 24 hypertensive patients with unilateral renal disease, the erythropoietin (Epo) concentration ratio in the renal veins was compared with the renin ratio. Seven patients showed moderately elevated peripheral Epo values. Epo and plasma renin activity were significantly positively correlated both in peripheral and renal veins. This suggests that the reduction of renal blood flow was a common, but not unique, stimulating factor of Epo and renin secretion. Epo ratio appeared insensitive since it was greater than 1.5 in only 30% of patients with a renin ratio > 2. Our results indicate that the Epo concentration ratio in renal veins cannot be proposed as a substitute for the currently used renin ratio.
在24例患有单侧肾病的高血压患者中，比较了肾静脉中促红细胞生成素（Epo）浓度与肾素比值。7例患者外周Epo值中度升高。外周血和肾静脉中Epo与血浆肾素活性均呈显著正相关。这表明肾血流量减少是Epo和肾素分泌的一个常见但并非唯一的刺激因素。Epo比值似乎不敏感，因为在肾素比值>2的患者中，只有30%的患者Epo比值大于1.5。我们的结果表明，肾静脉中Epo浓度比值不能替代目前使用的肾素比值。
