Menné T, Larsen K
Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark.
Semin Dermatol. 1992 Dec;11(4):278-83.
The naturally occurring 1,25(OH)2 vitamin D3 and the two synthetic derivatives 1,24(OH)2 vitamin D3 and calcipotriol (Calcipotriol, INN, Calcipotriene, USAN) have a profound effect on keratinocyte proliferation and differentiation. Clinical trials have shown an effect of all three derivatives in psoriasis. The limiting factor for the use of 1,25(OH)2 vitamin D3 is the risk of hypercalcemia, which is 100 to 200 times less for calcipotriol and that may be less also for 1,24(OH)2 vitamin D3. Presently, calcipotriol in an ointment base has been marketed in a number of countries and represents an alternative to treatment with topical glucocorticoids and dithranol.
天然存在的1,25(OH)₂维生素D₃以及两种合成衍生物1,24(OH)₂维生素D₃和卡泊三醇（卡泊三醇，国际非专利药品名称，卡泊三烯，美国采用名称）对角质形成细胞的增殖和分化有深远影响。临床试验表明，这三种衍生物对银屑病均有疗效。使用1,25(OH)₂维生素D₃的限制因素是高钙血症风险，卡泊三醇的该风险要低100至200倍，1,24(OH)₂维生素D₃的该风险可能也较低。目前，含卡泊三醇的软膏剂已在多个国家上市，是局部用糖皮质激素和地蒽酚治疗的替代疗法。
