自由基清除剂对急性皮肤移植中髓过氧化物酶活性和脂质过氧化的影响。
Influence of free radical scavengers on myeloperoxidase activity and lipid peroxidation in acute skin grafts.
作者信息
Goldstein R K, Augustin A, Milz J, Burg G, Lutz J
机构信息
Department of Dermatology, University of Wuerzburg, Germany.
出版信息
Adv Exp Med Biol. 1992;316:253-8. doi: 10.1007/978-1-4615-3404-4_29.
Activated neutrophil granulocytes are an important source of oxygen free radicals in acute skin grafts. Lipid peroxidation and immigration of PMNs, indicating inflammatory mechanisms, affect each other to a variable extent. The effect of the scavengers allopurinol and alpha-D-tocopherol on both lipid peroxidation and neutrophilic infiltration was investigated. A possible mechanism for the superior effect of allopurinol compared to vitamin E was discussed.
活化的中性粒细胞是急性皮肤移植中氧自由基的重要来源。脂质过氧化和多形核白细胞的迁移表明炎症机制，它们在不同程度上相互影响。研究了清除剂别嘌呤醇和α-D-生育酚对脂质过氧化和中性粒细胞浸润的影响。讨论了别嘌呤醇比维生素E具有更好效果的可能机制。
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