[孕期硫酸脱氢表雄酮（DHAS）的半衰期]

[Half-life of dehydroepiandrosterone sulfate (DHAS) during pregnancy].

作者信息

Cohen H, Cohen M M

出版信息

C R Acad Hebd Seances Acad Sci D. 1976 Jun 14;282(22):1875-8.

Abstract

During pregnancy the half-life of DHAS was measured after non tritiated DHAS infusion. At 30 weeks, the mean value obtained for DHAS half-life was 3.64 h +/- 0.74 and it was 3.67h +/- 0.38 at 38 weeks. The half-life of DHAS is shorter in pregnant than in non-pregnant women. Among 14 pathological pregnancies that we studied, 13 cases exhibited a DHAS half-life significantly longer than the average value obtained in normal pregnancies. In retarded fetal growth, the half-life of DHAS was more closely related to fetal than to placental weight.

摘要

在孕期，通过非氚化脱氢表雄酮硫酸盐（DHAS）输注来测定其半衰期。在孕30周时，DHAS半衰期的均值为3.64小时±0.74，孕38周时为3.67小时±0.38。孕妇体内DHAS的半衰期比非孕妇短。在我们研究的14例病理性妊娠中，13例的DHAS半衰期显著长于正常妊娠的平均值。在胎儿生长迟缓的情况中，DHAS的半衰期与胎儿体重而非胎盘体重的关系更为密切。