Ylöstalo P, Kauppila A, Reinilä M, Tuimala R, Ylikorkala O
Clin Endocrinol (Oxf). 1980 Feb;12(2):121-6. doi: 10.1111/j.1365-2265.1980.tb02126.x.
The aim of the present study was to determine whether pregnancy complications themselves influence the conversion rate of dehydroepiandrosterone sulphate (DHAS) to oestrogens during pregnancy. 100 mg DHAS was given intravenously to seven women with intrahepatic cholestasis of pregnancy, nine women with preeclampsia, nine diabetics, ten with twins and eight women with normal pregnancy between 31--40 weeks of gestation. Serum oestradiol (E2) and oestriol (E3) were measured with specific radioimmunoassays before and 1--5 h after DHAS injections. A significant oestradiol elevation following DHAS was similar in each group. By contrast there was an oestriol elevation (P less than 0.05) only in intrahepatic cholestasis of pregnancy. The results indicate that: (1) pregnancy complication itself does not effect the conversion rate of DHAS to oestradiol, (2) in patients with intrahepatic cholestasis there is a disturbed E3 metabolism which may be due to an increased placental permeability to exogenous DHAS or to a decreased metabolism of E3 by maternal liver.
本研究的目的是确定妊娠并发症本身是否会影响孕期硫酸脱氢表雄酮（DHAS）向雌激素的转化率。在妊娠31至40周期间，对7例妊娠肝内胆汁淤积症患者、9例先兆子痫患者、9例糖尿病患者、10例双胎孕妇和8例正常妊娠孕妇静脉注射100mg DHAS。在注射DHAS之前和之后1至5小时，采用特异性放射免疫分析法测定血清雌二醇（E2）和雌三醇（E3）。每组在注射DHAS后雌二醇均有显著升高。相比之下，仅妊娠肝内胆汁淤积症患者出现了雌三醇升高（P<0.05）。结果表明：（1）妊娠并发症本身不影响DHAS向雌二醇的转化率；（2）妊娠肝内胆汁淤积症患者存在E3代谢紊乱，这可能是由于胎盘对外源性DHAS的通透性增加，或母体肝脏对E3的代谢减少所致。
