早期三碘甲状腺原氨酸诱导的状态IV呼吸变化不受线粒体内膜质子通透性的调节。

The early triiodothyronine-induced changes in state IV respiration is not regulated by the proton permeability of the mitochondrial inner membrane.

作者信息

Horrum M A, Tobin R B, Ecklund R E

机构信息

Dept. of Internal Medicine, College of Medicine, Univ. of Nebraska Medical Center, Omaha.

出版信息

Biochem Int. 1992 Dec;28(5):813-21.

PMID:1337696

Abstract

The time course of changes in mitochondrial respiration, alpha-glycerophosphate dehydrogenase activity, and inner membrane proton permeability and the effects of protein synthesis inhibition was determined in hypothyroid rats treated with triiodothyronine. Respiratory rates, alpha-glycerophosphate dehydrogenase activity and proton permeability were decreased in hypothyroid rats and rose to euthyroid levels 9-12 hours after triiodothyronine treatment. Some rats received actinomycin D with the hormone to inhibit protein synthesis. Sixteen hours after actinomycin D and hormone treatment, the increases in respiratory rates and in alpha-glycerophosphate dehydrogenase activity, were completely inhibited. However, actinomycin D did not inhibit the increase in the membrane's permeability.

摘要

测定了用三碘甲状腺原氨酸治疗的甲状腺功能减退大鼠线粒体呼吸、α-甘油磷酸脱氢酶活性、内膜质子通透性的变化时间进程以及蛋白质合成抑制的影响。甲状腺功能减退大鼠的呼吸速率、α-甘油磷酸脱氢酶活性和质子通透性降低，在三碘甲状腺原氨酸治疗后9 - 12小时升至甲状腺功能正常水平。一些大鼠在接受激素治疗时同时给予放线菌素D以抑制蛋白质合成。在放线菌素D和激素治疗16小时后，呼吸速率和α-甘油磷酸脱氢酶活性的增加被完全抑制。然而，放线菌素D并未抑制膜通透性的增加。