涎蛋白血症：与植物血凝素或同种抗原诱导的体外淋巴细胞增殖抑制缺乏相关性。
Sialoproteinaemia: lack of correlation with inhibition of in vitro lymphoblastosis induced by phytohaemagglutinin or alloantigen.
作者信息
Gray B N, Kopito R R, Anderson L L, Baralt O L, Connery C K, Watkins E
出版信息
Clin Exp Immunol. 1976 Aug;25(2):227-33.
Elevation of serum-bound sialic acid concentration in different disease states fails to correlate significantly with suppressive serum actions in mixed allogeneic lymphocyte cultures or phyto-haemagglutinin cultures. Heat-decomplemented serum from patients with abnormal levels of bound sialic acid was added to parallel cultures containing similar blood lymphocyte populations derived from normal humans. Wide fluctuations of the rate of incorporation of tritiated thymidine into nucleoprotein indicated presence of suppressive elements other than sialoprotein in the added serum components. Serum with rising sialyl concentration derived from patients with cancer showed slight tendency to augment mixed lymphocyte and phytohaemagglutinin responses. The findings suggest that the previously documented nonspecific suppressive action of serum sialoprotein on human host lymphoblastic response to neuraminidase-treated cancer cells represents a mechanism unique to that culture system rather than a manifestation of a general immunoregulatory function of serum sialoprotein.
在不同疾病状态下，血清结合唾液酸浓度的升高与混合异体淋巴细胞培养物或植物血凝素培养物中的血清抑制作用无显著相关性。将结合唾液酸水平异常患者的热灭活血清添加到含有来自正常人的相似血淋巴细胞群体的平行培养物中。氚标记胸腺嘧啶核苷掺入核蛋白的速率波动很大，表明添加的血清成分中存在除唾液蛋白之外的抑制性成分。癌症患者来源的唾液酸浓度升高的血清显示出轻微增强混合淋巴细胞和植物血凝素反应的趋势。这些发现表明，先前记录的血清唾液蛋白对人宿主淋巴细胞对神经氨酸酶处理的癌细胞反应的非特异性抑制作用是该培养系统特有的机制，而非血清唾液蛋白一般免疫调节功能的表现。
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