Ren E C, Chan S H
J Natl Cancer Inst. 1981 Apr;66(4):625-30.
Sera from 23 hepatocellular carcinoma (HCC) patients were studied for their effects on lymphocyte proliferation during polyclonal mitogen stimulation and one-way mixed lymphocyte culture (MLC). The effect of 25% HCC serum on tritiated thymidine uptake of cultures varied from slight augmentation to 95% inhibition; however, no relationship was found between the potency of inhibition and serum alpha-fetoprotein (AFP) concentration. Purified AFP from the ascitic fluid of an HCC patient had no effect on MLC or cultures containing pokeweed mitogen; but at a concentration of 200 micro g/ml, AFP inhibited up to 30% of the proliferative responses in cultures containing phytohemagglutinin or concanavalin A. Results strongly suggest that the AFP in HCC sera is not inhibitory in itself.
研究了23例肝细胞癌（HCC）患者的血清在多克隆有丝分裂原刺激和单向混合淋巴细胞培养（MLC）过程中对淋巴细胞增殖的影响。25% HCC血清对培养物中氚标记胸腺嘧啶核苷摄取的影响从轻微增强到95%抑制不等；然而，未发现抑制效力与血清甲胎蛋白（AFP）浓度之间存在关联。从一名HCC患者腹水中纯化的AFP对MLC或含有商陆有丝分裂原的培养物无影响；但在浓度为200μg/ml时，AFP可抑制含有植物血凝素或刀豆球蛋白A的培养物中高达30%的增殖反应。结果强烈表明，HCC血清中的AFP本身并无抑制作用。
