晚期酒精性肝硬化患者血浆对PHA刺激的淋巴细胞转化的抑制作用。
Inhibition of PHA-stimulated lymphocyte transformation by plasma from patients with advanced alcoholic cirrhosis.
作者信息
Hsu C C, Leevy C M
出版信息
Clin Exp Immunol. 1971 May;8(5):749-60.
Abstract
Studies of lymphocyte transformation in patients with alcoholic cirrhosis of the liver indicate lymphocytes of such patients respond normally to PHA stimulation; however, their plasma or serum contains factors which block expected response to PHA. This effect was diminished by heating at 56°C for 60 minutes but was not affected by freezing and thawing. It could be overcome by increasing the dose of PHA. Blocking was also encountered in the response to pokeweed mitogen and Candida antigen stimulation but was not seen in the mixed lymphocyte reaction. Indentical results were obtained with plasma from patients with allergic rhinitis, uraemia, carcinomatosis, and granulomatous hepatitis. The magnitude of blocking effects in all of these conditions was negatively correlated with the serum γ-globulin levels.
摘要
对酒精性肝硬化患者淋巴细胞转化的研究表明，这类患者的淋巴细胞对PHA刺激反应正常；然而，他们的血浆或血清中含有阻碍对PHA预期反应的因子。这种效应在56°C加热60分钟后减弱，但不受冻融影响。增加PHA剂量可克服此效应。在对商陆有丝分裂原和念珠菌抗原刺激的反应中也发现了阻断现象，但在混合淋巴细胞反应中未观察到。过敏性鼻炎、尿毒症、癌病和肉芽肿性肝炎患者的血浆也得到了相同结果。所有这些情况下的阻断效应大小与血清γ-球蛋白水平呈负相关。
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