Chiang S R, Su W J, Lee P Y, Perng R P
Department of Chest Medicine, Veterans General Hospital-Taipei, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1992 Dec;50(6):509-12.
Many reports have shown that rifampicin could induce a variety of adverse effects. However, anaphylactic shock occurring after readministration of rifampicin, to our knowledge, has not been reported thoughtfully. Herein we present a case with anaphylactic shock after readministration of rifampicin. The possible mechanism may be the interaction between IgE antibody and mast cell or basophils. Compared with continuous regimen, intermittent rifampicin regimen has longer interval to accumulate more rifampicin-induced antibodies, and more immunogenic side effects are the sequelae when re-encountered with rifampicin.
许多报告表明,利福平可诱发多种不良反应。然而,据我们所知,再次服用利福平后发生过敏性休克的情况尚未得到详尽报道。在此,我们报告一例再次服用利福平后发生过敏性休克的病例。其可能机制可能是IgE抗体与肥大细胞或嗜碱性粒细胞之间的相互作用。与连续用药方案相比,间歇使用利福平方案有更长的间隔时间来积累更多由利福平诱导产生的抗体,当再次接触利福平时,更多的免疫原性副作用就会随之而来。