Kanny G, Maria Y, Mentre B, Moneret-Vautrin D A
Service de Médecine D, Centre Hospitalier Universitaire de Nancy, Hôpital de Brabois, Vandoeuvre.
Allerg Immunol (Paris). 1993 Dec;25(10):425-30.
A rare case of anaphylaxis to iodinated contrast media is reported. The patient underwent two anaphylactic shocks to intravenous administration of radiocontrast agents. Specific IgE were suspected on the basis of positivity of intradermal tests and human basophil degranulation tests. The passive sensitization of basophils from donors was performed, comparing native and heated serum. Results agreed with the hypothesis of IgE antibodies, since heating 56 degrees C during two hours prevented the degranulation. Considering the chemical structure, iopamidol was thought to be innocuous. Two opacification procedures were further performed with iopamidol without any incident.
报告了一例罕见的对碘化造影剂过敏反应的病例。该患者在静脉注射放射性造影剂时发生了两次过敏性休克。根据皮内试验和人嗜碱性粒细胞脱颗粒试验的阳性结果，怀疑存在特异性IgE。对供体的嗜碱性粒细胞进行了被动致敏试验，比较了天然血清和加热血清。结果与IgE抗体的假设一致，因为在56摄氏度下加热两小时可防止脱颗粒。考虑到化学结构，碘帕醇被认为是无害的。随后又用碘帕醇进行了两次造影检查，均未发生任何意外。
