Blundell J E, Hill A J
Department of Psychology, University of Leeds, UK.
Int J Obes Relat Metab Disord. 1992 Dec;16 Suppl 3:S51-9.
Dexfenfluramine has been demonstrated to produce decreases in daily energy intake varying between 13 and 25% depending on the time for which the drug has been administered. This reduction in energy intake is achieved by a decrease in the size of meals (11-40% depending on the dose) and by a decrease in the frequency of snacks consumed between meals. These objective adjustments are accompanied by a decrease in the level of perceived hunger, particularly apparent in the postprandial period. Taken together these changes can be interpreted as an action of dexfenfluramine to intensify the satiating power of food. This effect is consistent with the proposed role of serotonin systems in the mediation of satiety. The effect of dexfenfluramine on eating parameters leads to an overall modulation of the pattern of eating and the profile of motivation to eat. The reduction in energy intake achieved by this modulation is consistent with the weight losses recorded following several months of treatment. This restraint over the expression of appetite exerted by dexfenfluramine appears to be present even after 12 months of continuous treatment. These demonstrated actions should help overweight people to achieve a better management of their appetite in order to assist weight loss and to prevent weight regain.
已证实右芬氟拉明可使每日能量摄入量减少13%至25%，减少幅度取决于用药时间。能量摄入量的减少是通过减少餐量（取决于剂量，减少11%至40%）以及减少两餐之间食用零食的频率实现的。这些客观调整伴随着饥饿感的降低，在餐后阶段尤为明显。综合来看，这些变化可解释为右芬氟拉明增强食物饱腹感的作用。这种效应与血清素系统在饱腹感调节中所起的作用一致。右芬氟拉明对饮食参数的影响导致饮食模式和进食动机的整体调节。通过这种调节实现的能量摄入减少与数月治疗后记录的体重减轻一致。即使在连续治疗12个月后，右芬氟拉明对食欲表达的抑制作用似乎仍然存在。这些已证实的作用应有助于超重者更好地控制食欲，以辅助减肥并防止体重反弹。
