Appéré-De Vecchi C, Brechot J M, Rochemaure J
Service de Pneumologie, Hôtel-Dieu, Paris.
Rev Pneumol Clin. 1992;48(4):172-4.
The well-known neurotoxicity of cisplatin may be difficult to diagnose when the neuropathy it produces becomes worse during the weeks or months following the discontinuation of treatment or, exceptionally, appears at the time when cisplatin therapy is withdrawn. In addition, the drug-induced peripheral neuropathy must be distinguished from a paraneoplastic syndrome and in particular from epidural or radicular tumoral invasion. These different diagnoses are discussed in the light of the case reported here.
顺铂众所周知的神经毒性可能难以诊断,因为其引发的神经病变在停药后的数周或数月内恶化,或者在极少数情况下,在停止顺铂治疗时出现。此外,药物性周围神经病变必须与副肿瘤综合征区分开来,尤其是与硬膜外或神经根肿瘤侵犯相鉴别。根据本文报道的病例对这些不同的诊断进行了讨论。