Lai M W, Chang M H, Lee C Y, Hsu H C, Kau C L
Department of Pediatrics, College of Medicine, National Taiwan University Hospital, Taipei, R.O.C.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1992 Jul-Aug;33(4):264-72.
Fifty-five patients with cytomegalovirus (CMV)-associated neonatal hepatitis (NH) were followed for 12 to 90 months. Six patients (10.9%) died from either a fulminant course or a chronic liver disease. Among the remaining 49 patients, whose liver function was completely recovered, there were eight with retardation of developmental or growth status, and two with hearing impairment. Overall, 20.4% of the survivors suffered from a long-term impact. The unfavorable outcome was related to several clinical and pathological parameters. These included persistence of clay-colored stool, presence of splenomegaly, ascites or anemia, high peak total and direct bilirubin, low nadir albumin levels, diffuse giant cell transformation and cirrhosis of the liver. The seropositivity of CMV infection did not significantly correlate with the outcome.
55例患有巨细胞病毒（CMV）相关新生儿肝炎（NH）的患者接受了12至90个月的随访。6例患者（10.9%）死于暴发性病程或慢性肝病。在其余49例肝功能完全恢复的患者中，有8例发育或生长状况迟缓，2例有听力障碍。总体而言，20.4%的幸存者受到长期影响。不良结局与多个临床和病理参数相关。这些参数包括陶土样大便持续存在、脾肿大、腹水或贫血、总胆红素和直接胆红素峰值高、最低白蛋白水平低、弥漫性巨细胞转化和肝硬化。CMV感染的血清阳性与结局无显著相关性。
