Kondo M, Nakanishi K, Bamba T, Hosokawa K, Masuda M
Gastroenterology. 1976 Oct;71(4):631-4.
The tissue fibrinolytic activity of intestinal mucosa was studied in rats with protein-losing gastroenteropathies experimentally produced by X-irradiation, 5-fluorouracil treatment, or ligation of the thoracic duct. The first two models showed an increase of fibrinolytic activity and of 131I-polyvinylpyrrolidone excretion and the third showed normal fibrinolysis. In addition, it was demonstrated that 131I-polyvinylpyrrolidone excretion in the first two groups was markedly reduced by injections of trans-4-aminomethyl cyclohexane carboxylic acid, a potent antiplasmin agent. This finding affords strong support to the authors' previous clinical observation that tissue fibrinolysis in the digestive mucosa plays an important role in the pathogenesis of protein-losing gastroenteropathy associated with diseases of the mucosa.
对通过X射线照射、5-氟尿嘧啶治疗或胸导管结扎实验性诱导产生蛋白质丢失性胃肠病的大鼠的肠黏膜组织纤溶活性进行了研究。前两种模型显示纤溶活性增加以及131I-聚乙烯吡咯烷酮排泄增加，而第三种模型显示纤溶正常。此外，还证实，通过注射强效抗纤溶酶剂反式-4-氨甲基环己烷羧酸，前两组中的131I-聚乙烯吡咯烷酮排泄显著减少。这一发现为作者之前的临床观察提供了有力支持，即消化黏膜中的组织纤溶在与黏膜疾病相关的蛋白质丢失性胃肠病的发病机制中起重要作用。
