蛋白质丢失性胃肠病的新疗法。
New approach to protein-losing gastroenteropathy.
作者信息
Kondo M, Hosakawa K, Masuda M
出版信息
Lymphology. 1979 Mar;12(1):35-6.
Fibrinolytic activity in the biopsied gastrointestinal mucosa was investigated in patients with protein-losing gastroenteropathy, and the increased activity was observed in patients associated with erosive gastritis, Menetrier's disease, atrophic gastritis, or Crohn's disease. However, patients with intestinal lymphangiectasia showed normal mucosal fibrinolysis. Antifibrinolytic therapy with tranexamic acid revealed significant therapeutic effect in the group with increased mucosal fibrinolysis. It is concluded that tranexamic acid appeared to be successful in blocking the vicious circle of "membrane disorder","increased tissue fibrinolysis", "increased vascular permeability", and "hypoproteinemia" in protein-losing gastroenteropathy.
对蛋白丢失性胃肠病患者活检的胃肠道黏膜中的纤溶活性进行了研究，在伴有糜烂性胃炎、门脉高压性胃病、萎缩性胃炎或克罗恩病的患者中观察到活性增加。然而，肠淋巴管扩张症患者的黏膜纤溶正常。用氨甲环酸进行抗纤溶治疗在黏膜纤溶增加的组中显示出显著的治疗效果。得出的结论是，氨甲环酸似乎成功地阻断了蛋白丢失性胃肠病中“膜紊乱”、“组织纤溶增加”、“血管通透性增加”和“低蛋白血症”的恶性循环。
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