Andreenko G V
Nauchnye Doki Vyss Shkoly Biol Nauki. 1985(10):5-19.
A modern data review on the importance of fibrinolysis system is given. A considerable success has been scored during the study of molecular parameters of fibrinolysis system: the plasminogen, plasmin, its inhibitors, plasminogen activators and the mechanism of activation system have been characterized. The entrance of A, K, C, P and PP vitamins has been established to be necessary for the normal functioning of the fibrinolysis system; the dependence of the blood fibrinolytic activity upon the initial plasminogen content and concentration of its activators in blood has been revealed. The plasminogen activator depletion in tissues has been shown to be one of the reasons of some pathological states development, especially at cardiovascular diseases. The increase of fibrinolysis level by the active fibrinolytic ferment injection in blood has a medical effect at thrombosis. The ferment fibrinolysin received in the laboratory is successfully used in clinical practice. Some other activators of fibrinolytic system: tricholysine and longolytin from the culture of saprophyte fungi, plasminogen activator from the pig heart and the cells culture of the calf kidney have been received and are being studied.
本文对纤维蛋白溶解系统的重要性进行了现代数据综述。在纤维蛋白溶解系统分子参数的研究方面取得了相当大的成功：已对纤溶酶原、纤溶酶、其抑制剂、纤溶酶原激活剂及激活系统机制进行了表征。已确定A、K、C、P和PP族维生素的摄入对纤维蛋白溶解系统的正常功能是必需的；已揭示血液纤维蛋白溶解活性对初始纤溶酶原含量及其血液中激活剂浓度的依赖性。组织中纤溶酶原激活剂的消耗已被证明是某些病理状态发展的原因之一，尤其是在心血管疾病中。通过向血液中注射活性纤维蛋白溶解酶来提高纤维蛋白溶解水平对血栓形成具有医学作用。实验室获得的纤维蛋白溶解酶已成功应用于临床实践。已获得并正在研究纤维蛋白溶解系统的其他一些激活剂：来自腐生真菌培养物的曲古溶素和溶长链霉菌素、来自猪心的纤溶酶原激活剂以及小牛肾细胞培养物。
