Sokolovskaia N L, Moiseenko V M, Pozharisskiĭ K M, Semiglazov V F, Chernomordikova M F
Vopr Onkol. 1992;38(6):688-94.
Morphologic peculiarities of primary breast cancer versus growth rate were studied in 46 cases. Growth rate (actual doubling time) was established by mammography carried out at certain time intervals. Morphologic investigation included assessment of tumor histology, degree of invasion, growth pattern, presence of pathologic mitoses, degree of blood vessel invasion, degree of necrosis, presence of microcalcinates, type of desmoplastic reaction, peculiarities of cell infiltration, background and regional lymph node reaction, and grade of malignancy. None of the above parameters appeared to correlate with tumor growth rate. It is concluded that standard morphologic examination of tumor be supplemented with assessment of its proliferative activity.
对46例原发性乳腺癌的形态学特征与生长速率进行了研究。生长速率（实际倍增时间）通过在特定时间间隔进行的乳腺X线摄影确定。形态学研究包括评估肿瘤组织学、浸润程度、生长模式、病理性核分裂象的存在、血管浸润程度、坏死程度、微钙化的存在、促纤维增生反应类型、细胞浸润特征、背景和区域淋巴结反应以及恶性程度。上述参数均未显示与肿瘤生长速率相关。得出结论，肿瘤的标准形态学检查应补充其增殖活性的评估。
