Pugachev V F, Terent'eva N A, Torgushina N S, Rumiantsev A B, Sumina T V
Vopr Onkol. 1989;35(11):1352-4.
Clinico-roentgeno-morphological investigation established a marked regression of tumor in as many as 86.1% out of 230 patients with stage IIB and III breast cancer who had undergone radiothermotherapy. Morphologically confirmed complete regression was observed in 12.6% of patients with lesions smaller than 3 cm in diameter at presentation. Treatment was followed by massive necrosis, dystrophic changes and inhibition of mitotic activity of tumor cells in patients with stage III cancer and those with stage IIB who had presented with tumors larger than 3 cm in diameter. However, in all these cases viable tumor cells were still observed at the periphery of tumor.
临床X线形态学调查发现，在230例接受放射热疗的IIB期和III期乳腺癌患者中，多达86.1%的患者肿瘤有明显消退。在初诊时直径小于3 cm的病灶患者中，12.6%观察到形态学证实的完全消退。III期癌症患者以及初诊时肿瘤直径大于3 cm的IIB期患者在治疗后出现大量坏死、营养不良性改变以及肿瘤细胞有丝分裂活性受到抑制。然而，在所有这些病例中，在肿瘤周边仍观察到存活的肿瘤细胞。
