Peng Q
Tianjin of Endocrinology Institute.
Zhonghua Yi Xue Za Zhi. 1992 Nov;72(11):667-9, 702.
The effects of prostaglandin E 2 (PGE2) on the differentiation and proliferation of osteoblasts (human fetal bone-cells) cultured in serum-free medium were investigated by assays of alkaline phosphatase (ALP) activity, intracellular cyclic AMP level and collagen synthesis in the cells. The results suggested that PGE2 in physiologic concentration stimulated the differentiation of osteoblasts in vitro, and might be involved in bone formation in vivo.
通过检测碱性磷酸酶（ALP）活性、细胞内环磷酸腺苷水平及细胞中的胶原蛋白合成，研究了前列腺素E2（PGE2）对在无血清培养基中培养的成骨细胞（人胎儿骨细胞）分化和增殖的影响。结果表明，生理浓度的PGE2可刺激体外成骨细胞的分化，并可能参与体内的骨形成。
