Rivera Luna R, Martínez Guerra G, Ruano Aguilar J, Cárdenas Cardoz R, Lanche Guevara T
Gac Med Mex. 1992 Mar-Apr;128(2):97-104; discussion 104-5.
A total of 115 children with a histopathological diagnosis of Wilms' tumor were studied. The average age was three years. An abdominal tumor was the most frequent clinical manifestations, with a predominating clinicopathological stage II. The most important prognostic factors were the clinical stage and histological subvariety. A five year disease free period during the early stages was very favorable. On the other hand, advances stages and unfavorable histopathology established a poor prognosis. In our experience, stages I and II and favorable histology should not receive radiotherapy but instead brief chemotherapy. The global five year survival was 82%. All the patients with an unfavorable histology occupied stages II and IV. a comparison of disease free survival between stages I and II against III and IV showed statistical significance (p 0.01). Statistical significance also appeared upon comparison between unfavorable versus favorable (p 0.01) histology. Emphasis is placed upon multidisciplinary management of this type of malignant neoplasias.
共研究了115例经组织病理学诊断为肾母细胞瘤的儿童。平均年龄为3岁。腹部肿瘤是最常见的临床表现，主要临床病理分期为II期。最重要的预后因素是临床分期和组织学亚型。早期的五年无病期非常有利。另一方面，晚期和不良组织病理学预示着预后不良。根据我们的经验，I期和II期且组织学良好的患者不应接受放疗，而应接受短期化疗。总体五年生存率为82%。所有组织学不良的患者均处于II期和IV期。I期和II期与III期和IV期之间无病生存率的比较具有统计学意义（p<0.01）。不良与良好（p<0.01）组织学之间的比较也具有统计学意义。强调对这类恶性肿瘤进行多学科管理。
