剂量依赖性的维生素D3、25-羟基维生素D3和1,25-二羟基维生素D3诱导的高钙血症和高磷血症，以及安德森蟾蜍（Bufo andersoni Boulenger）终末鳃后体和甲状旁腺活性的相关变化。
Dose-dependent vitamin D3, 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3-induced hypercalcemia and hyperphosphatemia, and the correlative changes in the activity of ultimobranchial and parathyroid glands of the toad, Bufo andersoni Boulenger.
作者信息
Swarup K, Pandey A K, Hasan N, Das V K
机构信息
The National Academy of Sciences, Allahabad, India.
出版信息
Biol Struct Morphog. 1992;4(4):174-81.
PMID:1339166
Abstract
Vitamin D3, 25(OH) vitamin D3 and 1,25 (OH)2D3 were administered daily to unfed male Bufo andersoni for 15 days which resulted in a significant hypercalcemia and hyperphosphatemia in a dose-dependent fashion. 1,25(OH)2D3 is more potent than the other metabolites. The treatment activated ultimobranchial gland but induced degenerative changes in parathyroid of the toads.
摘要
每天给未喂食的雄性大蟾蜍施用维生素D3、25(OH)维生素D3和1,25(OH)2D3，持续15天，结果导致显著的高钙血症和高磷血症，且呈剂量依赖性。1,25(OH)2D3比其他代谢物更有效。该处理激活了后鳃腺，但诱导了蟾蜍甲状旁腺的退行性变化。
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