从包含X染色体基因座PGK1和DXS56的酵母人工染色体中分离DNTR多态性。
Isolation of DNTR polymorphisms from yeast artificial chromosomes encompassing X chromosomal loci PGK1 and DXS56.
作者信息
Graeber M B, Monaco A P, Chelly J, Müller U
机构信息
Division of Genetics, Children's Hospital, Boston, MA.
出版信息
Hum Genet. 1992 Nov;90(3):270-4. doi: 10.1007/BF00220077.
Five dinucleotide tandem repeat (DNTR) sequences were isolated from yeast artificial chromosomes containing the PGK1 and DXS56 loci in Xq13. Sequence information of these DNTR loci is given. Four of the five DNTR sequences were polymorphic. Polymorphism information content values were 0.44, 0.49, 0.47, and 0.76 for loci PY5-10, PY2-31, 4548-1, and 4548-7, respectively. Corresponding heterozygosities were 0.55, 0.55, 0.56, and 0.78. These DNTRs are useful for the fine mapping of disease loci in Xq13 and provide sequence tagged sites for this region of the X chromosome.
从包含Xq13中PGK1和DXS56基因座的酵母人工染色体中分离出五个二核苷酸串联重复（DNTR）序列。给出了这些DNTR基因座的序列信息。五个DNTR序列中有四个具有多态性。基因座PY5 - 10、PY2 - 31、4548 - 1和4548 - 7的多态性信息含量值分别为0.44、0.49、0.47和0.76。相应的杂合度分别为0.55、0.55、0.56和0.78。这些DNTR可用于Xq13疾病基因座的精细定位，并为X染色体的该区域提供序列标签位点。
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