Supramolecular selective transport of Ca2+/Na+ by dicarboxylic ligands across bulk liquid membranes.

Bulk liquid membrane transport of Ca2+ and Na+ ions was performed with dicarboxylic type ligands containing (S)-phenylalanine (Phe-2-O) and (S)-benzyltyrosine (Bz-Tyr-2-O) in pH gradients. With Bz-Tyr-2-O, calcium was generally favoured at every pH, the transport rate strongly depending upon the ligand concentration. At pH 8, a reversal of selectivity (Na+/Ca2+) was observed for the first time at low ligand concentration, thus suggesting that a supramolecular-type of transport occurs as a consequence of the different assemblages formed by the ligand according to pH and concentration. This is the first case of M2+/M+ selectivity induced by the carrier concentration.