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Synthetic cation transport peptides: calcium transport across phospholipid membranes.合成阳离子转运肽：钙通过磷脂膜的转运
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Molecular considerations relevant to the mechanism of active transport.与主动运输机制相关的分子考量因素。
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The stimulus-secretion coupling of glucose-induced insulin release. XLIII. Na-Ca countertransport mediated by pancreatic islet native ionophores.葡萄糖诱导胰岛素释放的刺激-分泌偶联。XLIII. 胰岛天然离子载体介导的钠-钙逆向转运
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Kinetics of transport of divalent cations across sarcoplasmic reticulum vesicles induced by ionophores.离子载体诱导二价阳离子跨肌浆网囊泡转运的动力学
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Sodium-calcium exchange and calcium-calcium exchange in internally dialyzed squid giant axons.内透析枪乌贼巨大轴突中的钠钙交换和钙钙交换
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Ionophoretic model for Na-Ca counter transport.钠钙逆向转运的离子电泳模型。
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大环载体分子对二价/单价钙/钾阳离子转运选择性的pH调节

pH regulation of divalent/monovalent Ca/K cation transport selectivity by a macrocyclic carrier molecule.

作者信息

Hriciga A, Lehn J M

出版信息

Proc Natl Acad Sci U S A. 1983 Oct;80(20):6426-8. doi: 10.1073/pnas.80.20.6426.

DOI:10.1073/pnas.80.20.6426
PMID:6312458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC394311/
Abstract

The lipophilic dicarboxylic acid-dicarboxamide macrocycle 1 is an efficient carrier for calcium and potassium transport through a liquid membrane. The process involves competitive Ca2+/K+ symport coupled to proton antiport in a pH gradient. It presents a very pronounced phenomenon of pH regulation of transport selectivity from preferential K+ transport to preferential Ca2+ transport as the pH increases from 2 to 9 in the starting aqueous phase containing the metal ions. The results demonstrate how carrier design allows control of the rate and selectivity of divalent/monovalent M2+/M+ cation transport.

摘要

亲脂性二羧酸 - 二羧酰胺大环化合物1是一种通过液膜进行钙和钾运输的高效载体。该过程涉及在pH梯度中与质子反向转运偶联的竞争性Ca2+/K+同向转运。在含有金属离子的起始水相中，随着pH从2增加到9，它呈现出从优先运输K+到优先运输Ca2+的运输选择性的非常明显的pH调节现象。结果表明了载体设计如何控制二价/单价M2+/M+阳离子运输的速率和选择性。