大环载体分子对二价/单价钙/钾阳离子转运选择性的pH调节
pH regulation of divalent/monovalent Ca/K cation transport selectivity by a macrocyclic carrier molecule.
作者信息
Hriciga A, Lehn J M
出版信息
Proc Natl Acad Sci U S A. 1983 Oct;80(20):6426-8. doi: 10.1073/pnas.80.20.6426.
Abstract
The lipophilic dicarboxylic acid-dicarboxamide macrocycle 1 is an efficient carrier for calcium and potassium transport through a liquid membrane. The process involves competitive Ca2+/K+ symport coupled to proton antiport in a pH gradient. It presents a very pronounced phenomenon of pH regulation of transport selectivity from preferential K+ transport to preferential Ca2+ transport as the pH increases from 2 to 9 in the starting aqueous phase containing the metal ions. The results demonstrate how carrier design allows control of the rate and selectivity of divalent/monovalent M2+/M+ cation transport.
摘要
亲脂性二羧酸 - 二羧酰胺大环化合物1是一种通过液膜进行钙和钾运输的高效载体。该过程涉及在pH梯度中与质子反向转运偶联的竞争性Ca2+/K+同向转运。在含有金属离子的起始水相中，随着pH从2增加到9，它呈现出从优先运输K+到优先运输Ca2+的运输选择性的非常明显的pH调节现象。结果表明了载体设计如何控制二价/单价M2+/M+阳离子运输的速率和选择性。
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