抗HPA - 4b（抗Yuk(a)）新生儿同种免疫性血小板减少症：一个白种人家庭中的首例报告
Anti-HPA-4b (anti-Yuk(a)) neonatal alloimmune thrombocytopenia: first report in a Caucasian family.
作者信息
Morel-Kopp M C, Blanchard B, Kiefel V, Joly C, Mueller-Eckhardt C, Kaplan C
机构信息
INTS, Service d'Immunologie Leucoplaquettaire, Paris, France.
出版信息
Transfus Med. 1992 Dec;2(4):273-6. doi: 10.1111/j.1365-3148.1992.tb00169.x.
Abstract
Neonatal alloimmune thrombocytopenia (NAIT) is caused by platelet antigen incompatibility between the mother and fetus. NAIT is mainly due to alloimmunization; the frequency varying among ethnic groups. In Caucasians HPA-1a is the antigen most frequently implicated. In Japan, NAIT due to anti-HPA-4b antibody has already been described, but this is the first case to be reported in Caucasians.
摘要
新生儿同种免疫性血小板减少症（NAIT）是由母亲与胎儿之间的血小板抗原不相容引起的。NAIT主要是由于同种免疫；其发生率在不同种族之间有所差异。在白种人中，HPA-1a是最常涉及的抗原。在日本，已经有关于因抗HPA-4b抗体导致的NAIT的报道，但这是在白种人中报道的首例此类病例。
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