涉及血小板同种抗体特异性抗原5b（Br(a)）的新生儿同种免疫性血小板减少症：1例罕见的日本病例。

Neonatal alloimmune thrombocytopenia involving HPA-5b (Br(a)): a rare Japanese case.

作者信息

Suda H, Ohto H, Tohyama Y, Morita S, Ishijima A, Ishikawa K, Chida S, Matsuda I

机构信息

Perinatal Medical Center, Morioka Red Cross Hospital, Japan.

出版信息

Acta Paediatr Jpn. 1995 Jun;37(3):399-400. doi: 10.1111/j.1442-200x.1995.tb03341.x.

DOI:10.1111/j.1442-200x.1995.tb03341.x

PMID:7645398

Abstract

Neonatal alloimmune thrombocytopenia (NAIT) is caused by platelet antigen incompatibility between the mother and fetus. The frequency of NAIT varies among ethnic groups. In Caucasians, HPA-5b (Br(a)) is the antigen that is second most frequently implicated. In Japan, NAIT due to anti-HPA-5b antibody is quite rare. The present case is the second case of Br(a)-NAIT in Japanese and the first case serologically confirmed by monoclonal antibody-specific immobilization of platelet antigens.

摘要

新生儿同种免疫性血小板减少症（NAIT）是由母亲和胎儿之间的血小板抗原不相容引起的。NAIT的发病率在不同种族之间有所差异。在白种人中，HPA-5b（Br(a)）是第二常见的相关抗原。在日本，由抗HPA-5b抗体引起的NAIT非常罕见。本病例是日本第二例Br(a)-NAIT，也是第一例通过单克隆抗体特异性血小板抗原固定法血清学确诊的病例。