Mei L, Pu S, Han J
Department of physiology, Beijing Medical University.
Zhen Ci Yan Jiu. 1992;17(3):179-82.
Continuous 6 hour's electroacupuncture (EA) of 2-15Hz or 2Hz applying to both legs of the rats resulted in the electroacupuncture tolerance (ET). Then, we observed: (1) The effect of 2-15Hz ET on the recovery of mean arterial blood pressure (MAP) and heart rate (HR) of rats after hemorrhagic shock; (2) The change in MAP and HR of rats subjected to 2Hz ET after intrathecally (i. t.) administration of DADLE 25 micrograms, a delta opioid agonist. The results showed that, firstly, there was no difference between 2-15Hz ET group and control group in the recovery of MAp and HR after hemorrhagic shock. Secondly, DADLE (25 micrograms) caused almost the same suppression effect both in 2Hz TE group and in control group. These results suggest that unlike the spinal dorsal horn cells (regulating algesia, the spinal lateral horn cells (regulating blood pressure) are insensitive during EA analgesia and can not be made tolerance to continuous EA.
对大鼠双下肢进行连续6小时的2 - 15Hz或2Hz电针刺激会导致电针耐受（ET）。然后，我们观察到：（1）2 - 15Hz电针耐受对失血性休克大鼠平均动脉血压（MAP）和心率（HR）恢复的影响；（2）鞘内注射25微克δ阿片受体激动剂DADLE后，2Hz电针耐受大鼠的MAP和HR变化。结果显示，首先，失血性休克后，2 - 15Hz电针耐受组与对照组在MAP和HR的恢复方面没有差异。其次，DADLE（25微克）在2Hz电针耐受组和对照组中产生的抑制作用几乎相同。这些结果表明，与脊髓背角细胞（调节痛觉）不同，脊髓外侧角细胞（调节血压）在电针镇痛期间不敏感，并且对连续电针不会产生耐受。
