Luo Y Q
Changhai Hospital, Shanghai.
Zhonghua Wai Ke Za Zhi. 1992 Dec;30(12):710-2, 777.
Immunoregulatory function of peripheral blood monocytes was studied in 20 patients with colorectal cancer, by assaying interleukin 1 (IL-1) and prostaglandin E2 (PGE2) in the culture supernatant of lipopolysaccharide-stimulated monocytes. The results showed that IL-1 activity of the monocyte culture supernatant was decreased in the preoperative patients, compared with that of controls or postoperative groups; the PGE2 content of the culture supernatant of monocytes from the preoperative cases was increased, compared to normal controls or to the postoperative groups. Again, we found that there was significant negative correlation between IL-1 activity and the PGE2 content, with the activity of IL-1 the lowest and the content of PGE2 the highest in advanced colonic cancer patients.
通过检测脂多糖刺激的单核细胞培养上清液中的白细胞介素1（IL-1）和前列腺素E2（PGE2），对20例结直肠癌患者外周血单核细胞的免疫调节功能进行了研究。结果显示，与对照组或术后组相比，术前患者单核细胞培养上清液的IL-1活性降低；与正常对照组或术后组相比，术前患者单核细胞培养上清液的PGE2含量增加。此外，我们发现IL-1活性与PGE2含量之间存在显著的负相关，在晚期结肠癌患者中，IL-1活性最低，PGE2含量最高。
