Chen S Z
Air Force Xian Hospital, People's Liberation Army.
Zhonghua Wai Ke Za Zhi. 1992 Dec;30(12):716-8, 777-8.
We studied 112 patients with polyps of the stomach, gallbladder and colorectum by immunohistochemical staining with monoclonal antibody (MG7) against gastric cancer and avidin-biotin complex (ABC) technique. The positive expression of the MG7-corresponding antigen (MG7-Ag) was 100%, 100%, and 60.0% respectively in villous, mixed and tubular polyps. A close correlation was shown between dysplasia of grade II and the positive expression of MG7-Ag (p < 0.05). The positive expression was significantly related to canceration (P < 0.025). No malignancy was found in 45 patients with negative expression. But 12 of 67 patients with positive expression developed cancers in 3 to 38 months. The patients with positive expression of MG7-Ag were high risk group developing cancer.
我们采用抗胃癌单克隆抗体（MG7）免疫组化染色及抗生物素蛋白-生物素复合物（ABC）技术，对112例胃、胆囊及结直肠息肉患者进行了研究。MG7相关抗原（MG7-Ag）在绒毛状、混合型和管状息肉中的阳性表达率分别为100%、100%和60.0%。II级发育异常与MG7-Ag阳性表达之间呈密切相关（p<0.05）。阳性表达与癌变显著相关（P<0.025）。45例表达阴性的患者未发现恶性病变。但67例表达阳性的患者中有12例在3至38个月内发生了癌变。MG7-Ag表达阳性的患者是发生癌变的高危人群。
