乳腺肿瘤胸苷激酶水平与疾病复发

Breast tumour thymidine kinase levels and disease recurrence.

作者信息

O'Neill K L, McKelvey V J, Hoper M, Monteverde H, Odling-Smee G W, Logan H, Abram W P, McKenna P G

机构信息

Department of Biological and Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland.

出版信息

Med Lab Sci. 1992 Dec;49(4):244-7.

PMID:1339926

Abstract

Thymidine kinase (TK) exists in two forms, TK1 and TK2. TK levels and oestrogen receptor status (OR) were measured in tumours from 86 patients with operable breast cancer and the patients were monitored for recurrence over 24 months. During the monitored period, 13 patients showed recurrence. These patients also exhibited higher total TK levels per mg tumour (P < 0.01) and higher TK1 levels (P < 0.001) than those who did not show recurrence. TK1 levels relative to TK2 were significantly higher (P < 0.05) in OR-negative tumours (n = 29) than in OR-positive tumours (n = 57). OR-negative (n = 9) and OR-positive (n = 4) patients who recurred had significantly higher TK1 levels relative to TK2 than did those who not recur (n = 20 and n = 53, respectively). These preliminary results indicate that breast tumour TK levels may have value in determining prognosis.

摘要

胸苷激酶（TK）以两种形式存在，即TK1和TK2。对86例可手术乳腺癌患者的肿瘤进行了TK水平和雌激素受体状态（OR）检测，并对患者进行了24个月的复发监测。在监测期内，13例患者出现复发。与未复发患者相比，这些复发患者每毫克肿瘤的总TK水平更高（P < 0.01），TK1水平更高（P < 0.001）。在OR阴性肿瘤（n = 29）中，相对于TK2的TK1水平显著高于OR阳性肿瘤（n = 57）（P < 0.05）。复发的OR阴性（n = 9）和OR阳性（n = 4）患者相对于TK2的TK1水平显著高于未复发患者（分别为n = 20和n = 53）。这些初步结果表明，乳腺肿瘤TK水平可能对判断预后有价值。